Based on Round table discussion at the 7th Int. Workshop on Clinical Pharmacology of HIV Therapy (20-22 April 2006, Lisbon, Portugal), an updated version of the TDM recommendations was defined.

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·         Omeprazole Almost Doubles Exposure of New Saquinavir Pill

·         FDA Gives Green Light to Darunavir for Treatment Experienced

·         Details on Tipranavir Failure in Treatment-Naive Trial

·         Significant Drop in Atazanavir Trough With Nevirapine

·         Efavirenz and Metabolite Inactivate 2B6 by Distinct Mechanisms

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·         Raising Nevirapine Dose Overcomes Effect of Rifampin

·         Lopinavir/Ritonavir Induces Hepatic CYP2C9, 2C19, and 1A2

·         Long-Term ddI May Raise Risk of Severe Liver Trouble

·         Modeling to Select Maraviroc Doses for Further Study

·         Simultaneous Esomeprazole Has No Effect on Fosamprenavir

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·         Prospective Genetic Screening for Abacavir Reaction

·         Evidence Backs Doubling NFV Dose on Day or Delivery

·         Population PK Model Developed for Nelfinavir in Children

·         Few NVP Toxicities in Pregnant Women of Mozambique

·         One Hint of Dysrhythmia in First Month of Atazanavir

·         Phase 1 Dose-Finding and PK Study of PI Brecanavir

·         Fenofibrate Almost Doubles Exposure of Ezetimibe

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·         Pediatric Antiretroviral Underdosing in UK and Ireland

·         Plasma Levels of 3TC Low in Children Under 6 Years

·         Cutting Fixed-Dose d4T/3TC/NVP for Kids Proves Risky

·         How Common Is Nevirapine Overexposure With Cirrhosis?

·         Enzyme Inducers That Shorten Nevirapine’s Half-Life

·         High Midazolam Levels With Saquinavir/Ritonavir

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All conference materials (presentations, abstracts and posters) from the

1st International Workshop on HIV and Hepatitis Co-infection 

can be found on www.HIVpresentation.com.